Specialized technology:

Our strong chemistry: Friedel Crafts reaction, Bromination reaction, Chlorination reaction, Grignard reaction,

Coupling reaction, Chiral asymmetric synthesis(including asymmetric reduction, alkylation), Heterocyclic

compounds synthesis, Reduction reaction, Hockman re-arrangement reaction, as well as other basic regular

reactions.

Friedel-Crafts reaction

Friedel Crafts is classical synthesis method of acylation processes.

Some examples:

Ar-H+R-COCl→Ar-CO-R+HCl

Grignard reaction

Grignard reaction is classical synthesis method of alkylation's processes. We routinely prepares and makes 

use of Grignard reagents for the manufacture of intermediates and active ingredients for the markets of 

Pharmaceuticals and chemicals. Syntheses are performed at scales between some tens of kg and more than 

500kg per batch because of local dry air condition.

R-X+Mg→R-MgX

RMgX + H₂O → RH + Mg(OH)X

RMgX + ROH →RH + ROMgX

RMgX + RCOOH →RH + RCOOMgX

RMgX + NH₃ → RH + NH₂MgX

RMgX + RNH₂ → RH + RNHMgX

RMgX + RC=CH → RH + RC=CMgX

Bromination reaction

Bromination reaction is classical synthesis method of Bromide series. 

CH₃COOC₂H₅ + Br₂ → BrCH₂COOC₂H₅ + HBr

ClCH₂C=CH + HBr →ClCH₂CH₂CH₂Br

3 RCOOH + PBr₃ → 3 RCOBr + HP(O)(OH)₂

Acyl chlorination

Sulfuryl dichloride, oxalyl dichloride, chlorine gas and chlorine hydride are often used as chloride agent. 

Some examples :

R-COOH + SOCl₂ → R-COCl + SO₂ + HCl

R-COOH + PCl₃ → R-COCl + HOPCl₂

Nitration

Organic compounds in molecules into nitro (-NO2) reaction. Aromatics of nitration is the preparation of 

aromatic nitro-compound the most important methods. Nitration reagent have nitric acid and denitration acyl 

bittern (NOX), four fluorine boric acid nitro cation, etc, and most important, the most commonly used is the 

mixture of sulfuric acid and nitric acid. 

Ar-H+HNO₃→Ar-NO₂+H₂O 

C₇H₈ + HNO₃ →C₇H₇NO₂ + H₂O